Herpes zoster post-herpetic neuralgia.

005 Nov;60(10):432, 436-7.

Feller L, Jadwat Y, Bouckaert M.

Department of Periodontology and Oral Medicine, Medunsa Oral Health Centre, Faculty of Dentistry, University of Limpopo, Medunsa Campus.

Post-herpetic neuralgia (PHN) is the most frequent complication of herpes zoster and often results in significant morbidity and a reduction in the patient's quality of life. The peripheral nerve injury that occurs during the acute phase of herpes zoster (HZ) leads to an abnormal tonic impulse discharge from primary nociceptive afferent neurons which induce slow temporal summation. This "wind-up" phenomenon is responsible for continuous partial depolarisation of second-order neurons with increased spontaneous impulse discharge and expanded receptive fields within the dorsal horn nociceptive neurons. The abnormal central processing involves the activation of N-methyl-D-aspartate (NMDA) receptors resulting in neuropathic pain, characterized by spontaneous pain, hyperalgesia and allodynia which is typical of PHN. In addition, tonic input from non-nociceptive AB afferent neurons, maintained by sympathetic efferent activity, contribute to the development and maintenance of neuropathic pain in general, and a burning sensation in particular.

PMID: 16438359

0 views0 comments

Our Address

Melrose North Medical and Dental Centre,

82 Corlett Dr,

Melrose North,

Johannesburg, 2196

We are located in: Suite C

Clinic location
  • Facebook

Dr. Yusuf Jadwat


Specialist in Oral Medicine & Periodontology including Dental Implantology

Clinic Hours

Mon - Thu: 8 am to 5 pm
Fri: 8 am to 4 pm

By Appointment Only

If you have any questions, concerns, or would like to schedule an appointment, please contact us today. We look forward to providing you with the personal care you deserve.

Contact Us

© Yusuf Jadwat 2020. All rights reserved. Created by Cool:Breeze