Cellular responses evoked by different surface characteristics of intraosseous titanium implants...

BioMed Research International

Volume 2015, Article ID 171945, 8 pages


Feller L, Jadwat Y, Khammissa R, Meyerov R et al, 2015.


The properties of biomaterials, including their surface microstructural topography and

their surface chemistry or surface energy/wettability, affect cellular responses such as

cell adhesion, proliferation, and migration. The nanotopography of moderately rough

implant surfaces enhances the production of biological mediators in the peri-implant

microenvironment with consequent recruitment of differentiating osteogenic cells to

the implant surface and stimulates osteogenic maturation. Implant surfaces with

moderately rough topography and with high surface energy promote osteogenesis,

increase the ratio of bone-to-implant contact, and increase the bonding strength of the

bone to the implant at the interface. Certain features of implant surface chemistry are

also important in enhancing peri-implant bone wound healing. It is the purpose of this

paper to review some of the more important features of titanium implant surfaces

which have an impact on osseointegration.

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